For people with Chronic Kidney Disease (CKD), healthcare professionals and organizations alike have agreed that the Arteriovenous (AV) fistula is the "gold standard" (best type) of vascular access, followed only by the synthetic graft for CKD patients on Hemodialysis. This is because the fistula has low rates of complications, clotting and infection. However, the new ready-to-use bioengineered blood vessels appear to be a safe and better substitute for the synthetic graft and even the AV fistula, according to results from trials that were presented at the American Heart Association on November 20, 2013.
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Jeffrey H. Lawson, MD, PhD (Duke University Medical Center) suggested that the artificial bioengineered veins not only further minimized the risk of clotting and infection, but also reduced the chance of "rejection." This "off-the-shelf" vein is built by cultivating human cells on a tubular scaffold to form a vessel-like shape which is then scrubbed clean of qualities that can trigger immune responses once it is implanted into a dialysis patient's arm.
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After a human trial, researchers found that the vein proved mechanically similar to native vessels and after 6 months there was adequate flow in all patients with no evidence of immune reaction, infection or signs of aneurysms. While Dr.
Lawson noted that longer follow-up and additional clinical studies are required to confirm preliminary observations, a notable milestone has been reached. The U.S. Food and Drug Administration has approved an Investigational New Drug application to evaluate the bioengineered vessels in a multicenter U.S. trial of CKD patients undergoing Hemodialysis.
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If the bioengineered veins prove effective and safe, KidneyBuzz.com believes it will be great news for the CKD Community who choose Hemodialysis as their main modality and currently deal with blocked veins from clotting, additional surgical procedures and high risk of infection when harvesting veins for a fistula or graft.
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Dalton, Kim. "Bioengineered Vessels Appear Safe for Use in Dialysis Patients - Journal News - TCTMD." Http://www.tctmd.com/. American Heart Association Scientific Sessions;
Laino, Charlene, Medpage Today and Everyday Health Staff Writer. "First Bioengineered Blood Vessel Implant Is a Success." Http://www.everydayhealth.com/. EverydayHealth Media, LLC