Chronic Kidney Disease Patients' Current Medication Regimens "Probably Too Low"

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Serious Staph Infections are more common in people with Chronic Kidney Disease (CKD) because they are frequently in hospitals and long-term care facilities where bacteria can germinate, highly vulnerable to blood infections due to arteriovenous fistula and dialysis catheters as well as receive medications that weaken their immune system. A new study reported online in the Journal of Antimicrobial Chemotherapy suggests that the antibiotic used to treat systemic and life-threatening infections, Daptomycin, is being prescribed in the incorrect dosage for people with "severe renal impairment." This limits the effectiveness of treatment to eliminate bacteria in the blood caused by deadly Staph Infections like Methicillin-Resistant Staphylococcus Aureus (MRSA).

Recommended Reading: New Treatment To Combat Deadliest Infection In Chronic Kidney Disease Patients, But Is It Too Disgusting?

MRSA infections are already highly drug resistant so prompt and appropriate dosing is critical to confine and remove the bacteria before it has the opportunity to burrow deep into a patient's body and potentially cause further life-threatening infections in bones, joints, surgical wounds, the bloodstream, heart valves and lungs. Since Daptomycin is primarily excreted by the kidneys, people with CKD especially those on Hemodialysis, Peritoneal Dialysis or recent Transplant Recipients must have a high enough concentration of the medication to treat the infection, but not so high that it causes Daptomycin related toxicity. 

Dr. Bruce Mueller, University of Michigan Health System Pharmacy Assistant Director, agrees with the study's findings that current drug concentrations for CKD patients are "probably too low." Dosing regimens currently suggest 4 mg/kg of Daptomycin every 48 hours. However, study trials suggest that by increasing a patient's regimen to 6 mg/kg then MRSA and other serious Staph Infections can be more effectively treated and corrected before further issues occur.  

Staph Infections on the skin including MRSA, generally start as small red bumps that resemble pimples, boils or spider bites. These can quickly turn into deep, painful abscesses that require surgical draining. Sometimes the bacteria remain confined to the skin but in other cases it has been known to infect bone, joints, major organs or contaminate the bloodstream. Do not ignore symptoms. recommends that you remain ultrasensitive to any rashes or irritations to your skin and immediately bring it to your Nephrologist's attention for necessary corrective action. 

*Note: Do not forget to order your All Purpose CKD Band!   

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"Study Refines Renal Dosing of Daptomycin for Staph Bacteremia." NewsDaily.

"MRSA : MedlinePlus Medical Encyclopedia." U.S. National Library of Medicine.

Staff, Mayo Clinic. "MRSA Infection." Mayo Foundation for Medical Education and Research.